![]() The sole driver event of MRT is the occurrence of biallelic mutations in the genes encoding SMARCB1 (INI1, 95% of cases) or SMARCA4 (BRG1, 5% of cases), the core subunits of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodelling complex 1, 2, 3. MRT, especially metastatic MRT, remain one of the most lethal childhood cancers, even following intense multimodal treatment. Although they may arise in any body part, MRT usually form in isolation or synchronously in the kidney and the brain (where they are referred to as atypical teratoid/rhabdoid tumours (AT/RT)). Malignant rhabdoid tumours (MRT) are soft tissue cancers that predominantly affect infants. Nature Communications volume 12, Article number: 1407 ( 2021) Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
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